In the same fixture last season, United came from behind to beat Northern rivals Liverpool 2-1 with goals from Rafael and Robin van Persie. The Old Trafford club will be hoping for a similar result this time, and if you believe reports, they’ll have to do it without Wayne Rooney.
The England striker has apparently been hospitalised after being accidentally kicked in the head by club captain Nemanja Vidic whilst training. After Rooney put in a Man of the Match performance against Chelsea last week, losing him for Anfield would be huge blow.
Liverpool have their own injury problems though, Kolo Toure looks set to miss out and Coates is still unavailable, meaning Liverpool may have to put together a makeshift back four.
Predicted starting XI
De Gea; Jones, Vidic, Ferdinand, Evra; Carrick, Cleverley; Welbeck, Kagawa, Valencia; Van Persie
Disagree with us? Leave your predicted XI in the comment box.