Following the 1-1 draw in Donetsk on Wednesday, United travel to the the Stadium of Light to take on struggling Sunderland in search of 3 vital points.
Rooney and van Persie who were doubtful, both play whilst youngster Adnan Januzaj makes his full debut.
The squad is as follows:
Confirmed XI: de Gea; Rafael, Jones, Vidic, Evra; Nani, Carrick, Cleverley, Januzaj; Rooney, van Persie.
Substitutes: Lindegaard, Giggs, Smalling, Hernandez, Welbeck, Valencia, Kagawa